Supplementary Table 1. R
2values of terminal phase regression for all analytes at each dose level.
PK parameter
s
Total irinotecan Mean (SD)
Free irinotecan Mean (SD)
SN-38 Mean (SD)
SN-38G Mean (SD)
Dose level (mg/m2)
30
(n=2)
60
(n=14)
90
(n=6)
120
(n=2) 30
(n=2
)
60
(n=14) 90
(n=6) 120
(n=2) 30
(n=2) 60
(n=14) 90
(n=6) 120
(n=2
)
30
(n=1) 60
(n=14) 90
(n=6
)
120
(n=2)
R2 0.9992 (0.0012)
0.9985(0.001 4)
0.9987 (0.0021)
0.9993 (0.0001)
0.9916 (0.0102)
0.9117
(0.1568)
0.9994 (0.0008)
0.9835 (0.0217)
0.9808 (0.0202)
0.9664(0.
0407)
0.9817 (0.0254)
0.9195
(0.0442) 1.0000 0.9886(0.0 100)
0.9793 (0.0366)
0.9215 (0.0308)
1
Supplementary Table 2. The proportion of AUC from observed last concentration to infinity for all analytes at each dose level.
PK parameters Total irinotecan Mean (SD)
Free irinotecan Mean (SD)
SN-38 Mean (SD)
SN-38G Mean (SD)
Dose level (mg/m2) 30
(n=2)
60
(n=14)
90
(n=6)
120
(n=2) 30
(n=2) 60
(n=14) 90
(n=6) 120
(n=2) 30
(n=2
)
60
(n=14) 90
(n=6) 120
(n=2) 30
(n=1) 60
(n=14) 90
(n=6
)
120
(n=2
) AUC _
%Extrap_obs (%) 0.84 (0.41)
0.71(0.35
)
1.16 (0.42)
0.62 (0.35)
4.87 (0.10)
4.23
(4.10)
1.34 (0.27)
1.52 (0.67)
12.42 (5.46)
6.90
(4.30)
4.63 (2.71)
7.02
(6.68) 11.29 6.78
(4.65)
9.86 (6.41)
7.18 (6.23)
2
3