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Fig. S1 Optogenetic stimulation of NAcGABA neurons does not fully rescue the risk-avoidance impairment in DISC1-NTM mice. A Sample gel showing the successful generation of DISC1/Vgat- ChR2 double-transgenic mice. B Representative confocal image showing targeted ChR2 expression (green) co-stained with GABAergic neurons (red) in the NAc in these double-transgenic mice (scale bar, 250 μm; inset, 10 μm). C, D Number of entries (C) and time spent in the open arms (D) before and after blue light (470 nm) stimulation during the EPM test (unpaired t-test, upper ***P = 0.0009, lower **P = 0.0014 (left) and 0.0066 (right); n = 8 left, n = 7 right).

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