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Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

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Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

Anne Walter, Apirat Chaikuad, Renate Helmer, Nadège Loaëc, Lutz Preu, Ingo Ott, Stefan Knapp, Laurent Meijer, Conrad Kunick

Supporting information

S2 Table: Results with compound KuWal151 (8c) in a crystal violet proliferation assay a

Cell line GI50 [µM] ± SD

HT-29 0.12±0.01

MCF-7 b 0.35±0.16

MDA-MB-231 0.28±0.05

RC-124 0.44±0.10

a experiments carried out in triplicate, SD = sample standard deviation

b experiment carried out in duplicate

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