02.04.2014
ETEAM Conference, 25th-26th March 2014, Dortmund 2
Background and aims of the
ETEAM Project
Dr. Martin Tischer
02.04.2014
ETEAM Conference, 25th-26th March 2014, Dortmund 3
Overview
• Observations
• Some characteristics of Tier 1 models
• Methodological approach and goals of the ETEAM project
• Organisational setup
Some observations (1)
Almost no measurement data provided in CSR
Almost all quantitative exposure estimates provided in the CSR are based on generic models (esp. TRA)
Other models are rarely used
Predictions are sometimes used
outside of the models recommended scope (e.g. aerosol exposure)
02.04.2014
ETEAM Conference, 25th-26th March 2014, Dortmund 4
Some observations (2)
Description of exposure
scenarios is often too vague and not detailed enough
Some PROCs are difficult to distinguish from each other (e.g.
professional/industrial)
ETEAM Conference, 25th-26th March 2014, Dortmund 5
?
Broad range of application but limited validation
ETEAM Conference, 25th-26th March 2014, Dortmund 6
V a l i d a t i o n D a t a
? ?
? ?
Generic determinants - an issue of uncertainty
• Task / PROC
• Volatility of substance/
Concentration in a mixture
• Efficiency of ventilation/
local exhaust ventilation
• Frequency/duration of task
ETEAM Conference, 25th-26th March 2014, Dortmund 7
8
ETEAM Conference, 25th-26th March 2014, Dortmund
8 8
Tiered approach:
LevelofConservatism
Uncertainty
low high
high • easy to use, screening tools
• broad range of application
• conservative predictions
• more complex models (e.g. ART)
• specific input required
• improved confidence in predictions
specific
measurements
Tier 1
Tier 2
Tier 3
low
Methodological approach of ETEAM
(Evaluation of Tier 1 Exposure Assessment Models)
ETEAM Conference, 25th-26th March 2014, Dortmund 9
External validation
Operational analysis
Conceptual Evaluation
ETEAM Conference, 25th-26th March 2014, Dortmund 10
Conceptual Evaluation
Questions of concern:
• Are the model assumptions plausible and consistent with established knowledge and theories?
• How uncertain are the model assumptions and determinants?
Used Methodology:
• Critical analysis based on
acclaimed literature knowledge
Operational analysis (human factor)
ETEAM Conference, 25th-26th March 2014, Dortmund 11
Questions of concern:
• Is the model understandable by, and of practical value to the
target group?
• Do different users arrive at the same results (reliability)?
Used Methodology:
• Evaluation of questionnaires, interviews and workshops
Assessment of the external validity
ETEAM Conference, 25th-26th March 2014, Dortmund 12
Questions of concern:
• Do the model estimates
correspond with measured data?
• How accurate and precise are the model estimates?
• What‘s the level of conservatism?
Used Methodology:
• Comparison of model estimates with independent measurement results
Data providers
• IFA
• BAuA
• NIOSH (Eun Gyung (Emily) Lee)
• TNO/ArboUnie
• SUVA
• EBRC
• HSE
• IOM / Fraunhofer ITEM
• Lund University
ETEAM Conference, 25th-26th March 2014, Dortmund 13
ETEAM Conference, 25th-26th March 2014, Dortmund 14
Models to be evaluated:
ECETOC TRA Versions 2 & 3 (inhalation and dermal)
Stoffenmanager Version 4.5 (inhalation)
EMKG-Expo-Tool (inhalation)
RISKOFDERM Version 2.1 (dermal)
MEASE Version 1.02.01 (inhalation and dermal)
EASE (conceptual evaluation only)
ETEAM Conference, 25th-26th March 2014, Dortmund 15
15
Project overview
WP I-2 Evaluation
of data sources
WP I-3 Data gathering/
reporting protocol WPI-1
Conceptual basis of
models
WP I-4 Data gathering/
populating database
WP I-6 Operational
analysis
WP II-1 Uncertainty
of Tier 1 models
WP II-2 Comparison
& suitability of models
WP 3 Dissemination Recommendations on applicability,
suitability and further development of the models
WP I-5 Data evaluation/
comparison with models
Project partners
ETEAM Conference, 25th-26th March 2014, Dortmund 16
Sponsor:
Federal Institute for Occupational Safety and Health, Dortmund, Germany
Martin Tischer, Urs Schlüter, Gudrun Walendzik, Ralph Hebisch
Contractors:
Institute of Occupational Medicine, Edinburgh, United Kingdom
Martie van Tongeren, Judith Lamb, John Cherrie
Fraunhofer Institute of Toxicology and
Experimental Medicine, Hannover, Germany
Susanne Hesse, Katrin Schroeder, Inge Mangelsdorf, Stefan Hahn
Quality control
International advisory board consisting of
Model developers:
ECETOC (Chris Money), TNO/ArboUnie (Hans Marquart, Henri Heussen, EBRC (Daniel Vetter) ), BAuA (Martin Tischer)
Major data providers:
IFA (Dorothea Koppisch), HSE (Christine Northage), SECO (Bojan Gasic)
ECHA participated as observer (Andreas Ahrens)
ETEAM Conference, 25th-26th March 2014, Dortmund 17
Role of the Advisory Board
• provide details on scientific assumptions of tier 1 models
• provide measurement data
• review of project deliverables
• attend meetings/telephone conferences,
• ensure objectivity in the validation process.
ETEAM Conference, 25th-26th March 2014, Dortmund 18
Dissemination
Project reports will be published on BAuA website
Planned series of publications in the Annals of Occupational Hygiene
Further presentations:
ETEAM Conference, 25th-26th March 2014, Dortmund 19
REACH Exposure Expert Group (REEG)
Dutch Occupational Hygiene Society Conference 2014
BOHS Conference 2014
02.04.2014
20 ETEAM Conference, 25th-26th March 2014, Dortmund
Thank
you
for your
Attention
ETEAM Conference, 25th-26th March 2014, Dortmund 21
