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New Naphthoquinone Derivatives from the Ascomycete IBWF79B-90A

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New Naphthoquinone Derivatives from the Ascomycete IBWF79B-90A

Anja Schüffl era, Johannes C. Liermannb, Heinz Kolshornc, Till Opatzb, and Heidrun Anked,*

a University of Kaiserslautern, Paul-Ehrlich-Str. 23, D-67663 Kaiserslautern, Germany

b Institute of Organic Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany

c Institute of Organic Chemistry, University of Mainz, Duesbergweg 10 – 14, D-55128 Mainz, Germany

d Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany. E-mail: anke@ibwf.de

* Author for correspondence and reprint requests

Z. Naturforsch. 64 c, 25 – 31 (2009); received September 23/October 24, 2008

Bioactivity-guided fractionation of extracts from the fungus IBWF79B-90A resulted in the isolation of three known naphthoquinones, herbarin, dehydroherbarin, and O-methylher- barin and the azaanthraquinone scorpinone as well as three structurally related derivatives, O-phenethylherbarin and herbaridines A and B. All seven compounds exhibited cytotoxic activities against several cell lines.

Key words: Naphthoquinone, Herbaridine, Cytotoxic Activity

NC_8221_schueffler.indd 25 19.02.2009 17:06:40

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