A cost impact analysis of clonoSEQ
®as a valid and CE-certified minimal residual disease (MRD) diagnostic compared to no MRD testing in multiple myeloma in Germany
Stefan Walzer
1,2,3, Sebastian Krenberger
1, Lutz Vollmer
1,4,5, Tony Hewitt
6, Benjamin Eckert
61
MArS Market Access & Pricing Strategy GmbH, Weil am Rhein, Germany
2
State University Baden-Wuerttemberg, Lörrach, Germany
3
University of Applied Sciences Ravensburg-Weingarten, Germany
4
University of Applied Sciences Rottenburg / Neckar, Rottenburg, Germany
5
University of Tübingen, Tübingen, Germany
6
Adaptive Biotechnologies, USA
Corresponding author:
Sebastian Krenberger
MArS Market Access & Pricing Strategy GmbH Geffelbachstraße 6
79576 Weil am Rhein, Germany Tel: +49 173 27 45 716 (phone)
E-Mail: sebastian.krenberger@marketaccess-pricingstrategy.de
Supplemental Material
Table 1a Total costs for MRD testing vs. no MRD testing per patient over 1, 3 and 10 years – probabilistic analysis
Period Total costs for MRD testing
95 % CR Total costs for no MRD testing
95 % CR Total incremental costs for MRD testing vs. no MRD testing
95 % CR
1 year €75,494 €61,548 -
€89,575
€93,047 €74,858 -
€89,575
-€17,553 -€24,052 - -€11,862
3 years €201,688 €160,975 -
€238,233
€256,342 €209,068 –
€238,233
-€54,654 -€84,756 - -€32,883
10 years €392,592 €237,115 -
€482,138
€452,626 €293,009 -
€482,138
-€60,003 € -€92,080 - -€35,731
CR Confidence range, MRD minimal residual disease; all cost data were rounded to the full amount
Table 1b Total costs for MRD testing vs. no MRD testing per patient over 3 years – one-way deterministic sensitivity analysis, MRD status at baseline
MRD status positive at baseline
Total costs for MRD testing over 3 years
Total costs for no MRD testing over 3 years
Total incremental costs for MRD testing vs. no MRD testing over 3 years
65 % €161,319 €248,876 -€87,557
70 % €170,206 €248,980 -€78,774
75 % €179,094 €249,084 -€69,991
80 % €187,981 €249,188 -€61,207
85 % €196,868 €249,292 -€52,424
CR Confidence range, MRD minimal residual disease; all cost data were rounded to the full amount
Table 1c Total costs for MRD testing vs. no MRD testing per patient over 10 years – probabilistic sensitivity analysis, MRD assessment intervals
MRD assessmen t interval
Total costs for MRD testing
95 % CR Total costs for no MRD testing
95 % CR Total incremental costs for MRD testing vs. no MRD testing
95 % CR
Every 3 months
€401,067 €249,399 -
€489,298
€452,056 €290,223 –
€489,298
-€50,999 -€87,092 - -€23,783
Every 6 months
€392,592 €237,115 -
€482,138
€452,626 €293,009 -
€482,138
-€60,003 € -€92,080 - -€35,731
Every 9 months
€391,470 €229,882 -
€482,553
€452,865 €285,383 -
€482,553
-€61,394 -€90,805 - -€38,566
Every 12 months
€392,082 €237,259 -
€483,803
€452,445 €290,301 -
€483,803
-€60,363 -€86,097 - -€39,894
CR Confidence range, MRD minimal residual disease; all cost data were rounded to the full amount
Table 1d Total costs for MRD testing vs. no MRD testing per patient over 3 years – probabilistic sensitivity analysis, MRD assessment intervals
MRD assessmen t interval
Total costs for MRD testing
95 % CR Total costs for no MRD testing
95 % CR Total incremental costs for MRD testing vs. no MRD testing
95 % CR
Every 3 months
€210,816 €168,877 -
€248,876
€256,357 €209,592 –
€248,876
-€45,542 -€79,334 - -€21,486
Every 6 months
€201,688 €160,975 -
€238,233
€256,342 €209,068 –
€238,233
-€54,654 -€84,756 - -€32,883
Every 9 months
€199,886 €159,511 -
€236,119
€256,123 €207,655 -
€236,119
-€56,238 -€83,283 - -€35,732
Every 12 months
€201,194 €163,064 -
€235,271
€256,810 €208,902 -
€235,271
-€55,616 -€80,027 - -€37,362
