• Keine Ergebnisse gefunden

Funktionelle Analyse von Rho-spezifischen Guaninnukleotidaustauschfaktoren in Ustilago maydis

N/A
N/A
Protected

Academic year: 2021

Aktie "Funktionelle Analyse von Rho-spezifischen Guaninnukleotidaustauschfaktoren in Ustilago maydis"

Copied!
200
0
0

Wird geladen.... (Jetzt Volltext ansehen)

Volltext

(1)0123244567829 52

(2)

(3)    1. 21232. 6 8

(4) 26.  !! "#!$% &'()%* +,%-(  .#!/#%#%-(0#123456789:7;<53 =255

(5) 

(6) 28 > ? 388@ 5=

(7)   @ 5 @ A

(8)  B255 851C

(9) 8 D= E E8

(10) EF @ G 1. 21232. @ 0123244567829 52

(11)

(12)    9  3 

(13) 98 H#$I!&1J-( KLMNOPQ.   RS18TUVU.

(14) 01234567898 56 1

(15) 1 8896

(16)  89 4979 4

(17)  894 1 424 81228 9 45689!91"9 #

(18) $89 %&8  45689!91"9''8$4& (16

(19) )4 892*

(20) 5689*" 42!+9(.

(21) 01213425675812923423 5 21

(22) 4 5925

(23) 233

(24) 25  3923 5423671 1022 253

(25) 1

(26)

(27) 5232

(28) 1425 181!!"316251

(29) #

(30) 5 59 3

(31) 25425 $21

(32) 39673 57%05%128&'8254 5925

(33) %. (218241225 5 21

(34) 1341342378923423 5

(35) 1283625')23

(36) 81

(37) * +13,-%.%,34&'825,%/0% 1775413

(38) 17372

(39) 71321342882!5

(40) 173 2234778

(41) 592

(42) 1397143"!214 9 31323 827

(43) 14225392

(44) 75136789:;<=>;?@97%78&1781288/A0,BCB"BCC% D8 2, %,+13,-%.%,825

(45) ,%,+3457,&%,34&'825,%/C0% +282

(46) 162

(47) 16

(48) 173 2

(49) 29 31323 827

(50) 14225392

(51) 75073B11342

(52) 251" 33

(53) 714319388139!2141

(54) 2136789:;<=>;?@97E78157 178FC,FB"FA% G51225,+%D%,+13-%.%,D8 2, %,34&'825,% 0175!11

(55) 139136789:;<=>;?@971367862329

(56) 162224 529 8

(57) 1737

(58) 2 HB"!214H7"IG143/13J75 2521

(59) 390 +13,-%.%,K25,%,34&'825,% -13213"241

(60) 244281625272572

(61) 162182151

(62) 18752882!5

(63) 17334!785 957

(64) 136789:;<=>;?@97/13J75 2521

(65) 390 .

(66) 012345640735854.

(67) 0123456789 8

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

(69) 0123456789 8

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

(71) 0123456789 8

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bcY Y Z[\]^8[_;=`Z]\a<`]= A d$'!*5."e%!E44 A1 AA d$'!*%!E44 A1 A e%!E44 A1 A@ fghi5B!E44 A1W A "*%X/*!+%!!B!E44 A1  I$%4*"."I*4 A1J  A B!$"$"5I$%4*" A1J   I$%4*"M"*H$%4$!*) A1J  @ I$%4*"M"*I".'!*)'4/*$!I!**jkigA@1 @ T.!*)*. )-*'$*%4 A@ @A T.!*)*. )jklmnklkigojkigp A@ @ #$C*!$. )jklmnklkig A@ @@ T.!*)*. ) A@ @ #$C*!$. )  A@ @W T.!*)*. )qkklnikmkmnmrm  A@W @ #$C*!$. )qkmnmrm  A@W  -'.$/**%&+H&+*' A@W ,.

(73) 0123456789 8

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` *T*J  1 51 :*3*+,_+,"E4/9 9:  5 \.

(75) 0123456789 8

(76) 21 6   !"#$%&&'()* +,,+-, .  / 0*1234(567869:8!6;6<6678= . / > 567869<?<@<<A978=B6<CDEA F G  . / H I@978567869JKL+-'2, . > H. M?JKL+-'2,I  . > HN IO<=G@69  . > .PM  . H .P.9 M  . H .PNQ6RS8   . H ..6T6<UV69 .W. ...UV69=X< < YZ78UY[ .W. ..NUV69=X<9!?8 .W. ..\"68Q6T .WN .. 6T=X"F"!?86<]Q  .WN ..WUV69=X<B6978 78 ?I .W\ ..UV69=X<?696<#= JKL+-'2,.W ../6T=X<6=969 .W ..>6T=X2*1234(!AC .WW .NM@978;G8 < .W .N.;G8 <=X<^669JKL+-'2,  .W .NN;G8 <=X<^669_K`a4a12,2+a .W/ .N\;G8 <=X<^669<Q6 bK`(&2 .W> pqr cdefgheigjfgkfdlmndo stuvgkinwfn pxy pxq zhnuohwinw cftfno{hi| pxx }d~fooehee{dlmf}gu{ginw px€. E.

(77) 01123456789

(78) 2 628   !"#$ & '(!(")$!(*!( , -.!/*0#$ 2 340/!(4056!*0#$ % !40")$!(*0#.!/ + -*942&:;<=>=?@A@B=  1 340/!(4066-/C((*0#"D.( 7 *0#"D.(-6#.!/ 8 *!C*0#"D.(  E3*!FF( -*$0(F0!G#(#$0(F0!6H!(! C'/F!/  &3(DI4G(#'/FI  ,-DI4G(#'/FI!(JK(40L($!(/!# //6!  2(DI4G(#'/FI40*0#")$!( %-M6(G(NAO@PBQRSBTU@A +F0V<U<WX#V>B<Y#!  1*0#"D.(N;SBTU@A 7-(/!(."-#K!"D.(-ZG# (5 8-*0#"D.94&2(!/F![!40(/6 &E 3F\C(K40(942&*!440(!(40# /(C &"D.(!/FI3!K  & 340/!(40-!((@]?@O>R"D.#((!G( && 5942&^*!4^942&_`ab *!4b`a_ (K-c# -/C-  &, -(942&#(F\(40"D.  &2 94&2(*!4#(F\(40"D.  d. % + 1 7 8  + 1 8 &E & &2 &% &+ &7 ,E ,& ,, ,2 ,% ,1 2E 2 2& 22.

(79) 01123456789

(80) 2 628   !"#!$%&'()*&'&' +,-.(/&*-! 1  !"2$%&'(3&045&!67!&' -.(/&* 8 9(-.(/&*-&':)*!&'-!&';-< =>!7-(<5 @ )9<!%--!-!&'/&*ABCD +,'7-<E&'!5 !" F"#  ? )9(-.(3&0-&'3&0<H.5&'65!E&'!-<  *GI,7-.!5>!!)*"! **):JI")<%4'&'!67!&' #!KLM  *):JI")<%(<5N5!()*  *L):JI")<%55!)*!< *0!<5I!5-&'5-+%-<5&'/.!O%' =55-. *)*".!<O(< P!"6PL 5.(-4-5!6 *1)=555-.!+(QRSTU"-VWTX"-!-+YH" -.(-!&'5&'&'!<7-,&7-+,' *8Z4[6!!!:!)*+,'7-/--.(3&0 !<5I!5 *@\.!!9"=>!5!Q]R]^_`QRSTU"- *?)9!--< !-%Y6-< O7$%&' 7O!&'!<-=>65!<.45  G)![&>!"abTRcbdV"Y&L.<5 ! 3&0-/&*  *))5!abTRcbdV"!Y&L+,'7-)+<P-7-.!" ('5  ))5!abTRcbdV"!Y&L+,'7-!<6'5.!&' )+ L)[&>!"P<65[55!<O&'!=5565 0Y!&'I!555!P!6!67-<2&' Y6-.!7 Y!&'I!5!'&'><!&'-O,45.Y& !6  1)=!H-.!-4-5"=>!5!+,'7-< I5-!Y&0" I!54O.-.  e. 01 08 0? G *  L 0 1 8 @ ? 1G 1 1L 1 11 18 1@ 1? 8* 8.

(81) 01123456789

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

(83) 012344567322168 9

(84)   

(85)

(86)  

(87)       ! 

(88)

(89) "

(90) # $ #.  % #  & !    '

(91)  (

(92) !

(93)   )!

(94) #*! !!& +.  , 

(95) !%!  " 

(96)  ! ,!-.  $

(97)   )'

(98) !/    ), !  

(99)  012 3

(100)   ,*!,! 

(101) #456789:;<9=>75  ! !+

(102) /  ! !&/

(103)

(104) , ?  

(105)   

(106) , #

(107) @ 

(108)   /

(109) ! 

(110) !  /%

(111) ! !/   -

(112) '!  !

(113)  )!

(114) $!  AB ! &   

(115) '!-

(116)  ! $    

(117)  )!

(118) $!!

(119) 

(120) !/   

(121)  

(122) !  

(123) AB !!

(124) $

(125)  

(126) #

(127) !

(128) 

(129) !

(130)  . ! !

(131) 

(132) !

(133)  , #

(134) @CD $

(135) AB ! 

(136) !   

(137) 

(138) ! 

(139)  -A!. !

(140)  

(141)  &/

(142) 

(143)   !. !/

(144) & 

(145) 

(146) !

(147)  

(148)    !/!

(149) , #

(150) @ !

(151)    !-E

(152)  012 3#

(153) 

(154)  FG  H #

(155)  !

(156) !%!&' 

(157) E !

(158)  

(159)   !

(160)

(161) 4I<9=>75J!#$.   ! 

(162) 

(163)  % !*, -E 

(164)   012 3

(165)  ! 

(166) 

(167)  

(168)    -)J  )'

(169) ! / '  !&

(170) 012 3, #

(171) @!%!$

(172) 

(173) #

(174)  )

(175) %  

(176) !

(177)   KL 

(178)  ' !

(179) !/

(180) -A

(181) )!

(182)  )

(183) %

(184) 3 J!#

(185)  !

(186) 3MNOP&/ 

(187)  !

(188)  $ 012 $ 3 J.  -A' !

(189) B!

(190) J  , 

(191)   )!

(192) 012& 012PNOM &#-)   (

(193)  /'  !&

(194) )

(195) %  

(196) !

(197)  KL

(198) /

(199) !

(200)  . J

(201) , #

(202) @ A  $ 012 3

(203)   !

(204) !! ,

(205) !-E /  ! !&/  . 

(206) )!

(207) $

(208)   $  

(209)  !

(210) !! '

(211)  , #

(212) @!%! ! 

(213)  !

(214)  ,

(215) !-F

(216) !Q

(217) 

(218) 7RS76T;*!  !  #

(219) !/  & A E 3, #

(220) @ U !

(221) !   012! *

(222) !& /%    J'   $ / !  3

(223) !

(224) !-

(225) #

(226) !

(227) 

(228) !

(229) )

(230) % ! 

(231) !

(232)  KL$ 012 3&

(233) )!

(234) $

(235)  $ 3MNOP E 3#  ' -E

(236) )

(237) %  

(238) !

(239)  KL

(240) !

(241) #

(242) !

(243)   

(244) !

(245)  !J

(246) A  $ 012E 3#

(247) -J A021 !  #

(248) !/  &

(249)  ,%  !

(250) . 3!

(251) $

(252) !-)

(253) '

(254)

(255) !

(256) )

(257) %  

(258) !

(259)  KL

(260) /

(261) !

(262)  !J

(263) A    2.

(264) 01123456789

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

(266) 01234526738 090

(267) 23535

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`aGb)!!="+)!6D(EFQF7.:% -15!!;'8"%4)!!'. c.

(269) 01234526738. 9 9 9

(270) 

(271) 

(272) 

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`_. ^Yf. ^a_. ^a_Se[. QRSTUVW. ^a_Se[. ^a_Se[. ^a_. ^`_. YZZ[TU\][R. ^a_Se[. _V. ^a_. ^X_. XTUVW. bc d. ..%#4&3D5Dghijkllmnopqrstskonuvnujwuxqrstskonuvtiuqlksukuyz{oirksuku| I%&'7)$2&,$#&#4$:0#&4+*4+:0!2&')84'()#4$:0'@1+*!$ 4&#& #+$*!$&12$/*4;@K2$&&,$&5<H#$2%H+!2&'()C,%:0#4$:0')+ /2#4%$ ,$#&*&&C;-0$ 84$L&*!$4&3#+'7)$2&+. L/ 1*%%#$60274&#6*.7"0&%:0&'()*+&3. +,$1*2$&C,%:0#7 !" #$'()*+&.&}4++&J&&&5<$.0*&#% ++:04/ #+23&*&&& ~€‚ƒ„ ƒ†‡‚ˆƒˆ‚‰‰†„‚€‡‚†‚Š‚‹‚‡†Œ‰='L+A=P4 *%5CDEEŽN*.$**&#P*+/$C FFŽ$9*$#$2++*&*&#B22:0CFF‘A5+)$2&J&&&//.$*&3.4&#&'7 )$2&.&#&4&#*4+#$9/.$*&0$*4+%J+&5!2&'L+3.4&#&&)$2& %3&&#$&*!&12$//’H2O%*+/*!2$5 NJ$4&3&.#$634%*2&#$%&&'()*+&;-0$&2; 84&$4&2&$2%%$& ’%%O$2%;$*2&4&##*/84$(4/2$&+04&3584$+ *%+M&23&#&“8$& 6*+7)$2& $*3&&#$63%94*2&&C#0$'()*+7!" .%2:$&4&# ‘.

(274) 01234526738. 9.

(275)  !"# $%&'()*++,+,&(+-."-) / &("0+1,*+,+,2,*3 4 565 7 589:5;<78=><58?;< 7@AB <CD>E9F 7GH85I=IJK G<87<F?8; 58<E 565 7 58L9M=><58?;< 7@AB <CD>>E9F 7GH85NO=PNK G<

(276) ?F?8; 58<. G 5 ?F <  58LQR=5  55M78F?885< 585@S7GETJTK4?6?G=LQR?G5? 58 65

(277) ?< 7 58U5

(278)

(279) <5

(280)  8CDV?CDG<FGW?;<785 5<5

(281) <G  EWXD8<5 5 ?58D?W<5 A< F

(282) 58 58U5

(283)

(284) Y87

(285) W58?< 7

(286) 5<Z<5

(287) CDZ8QF785<G<5D@S7855<?

(288) ETTK. [\[\]^_`ab_a`cdebfghegeijklmge. 4 5A<8;<8 58;

(289) 5 5L=R87<5 5 G<D7CD;7G58n 58<9.

(290) Z5 < 5 85 = F5G 7?

(291) 5A<8;<8 58;

(292) 5 5LQR?G56?G@o=6?GK?GAH5< 5854?Gp7

(293) 5;X

(294). 5G<5D<?Gqr=s5

(295) C5G Nt=M?

(296) <

(297) H<<58@V << D7W58? R? ETTK4 565 7 589:5;<78=><58?;< 7B8 587<F?8; 58<E 565 7 58L9M=><58?;< 7

(298) ?u5=. 5 5R87<5 5 586?G=M?F

(299) 5B8 57CDqB5 <585R87<5 W?F

(300) 5 5< vZ 58<E 5?W8 D858wD

(301) CD;5 <ZF 6?G=R87<5 Z86?G=AY58W?F

(302) 5ZG?FF55W?GG< B8 5@Q?;? 5<?

(303) EOOK4 5G5R87<5 5HD5

(304)   D858A5x5Z A<8;<8 5 6?G=LQR?G5EX 585DF5? 58? 585Z5

(305)

(306) 

(307) H859W? 54 5R87<5 5 586D7=M?F

(308) 5 @6D7y6?GD7F7

(309) 7zKB8 5Z58G<?D? D858A5x5ZHD

(310) CD;5 <ZF6?G=R87<5  5< vZ 58< D? 5M;< 75 5 58Uz<7G;5

(311) 5<<={8? G?< 7@R?<58G75<?

(312) ETTO| s?

(313)

(314) ETT|S7GETJTK4 5R87<5 5 586? = A?8}98W=M?F

(315) 585

(316) 585 5 <8?= Z5

(317)

(318) 

(319) H85~5G ;5

(320) <8?GY78<@R

(321) <585<?

(322) ETT|A<5F?8;EOOTKEBHD85 5R87<5 5 586?=M?F

(323) 5D?Y<GHCD

(324) CD 59G<?GCDn7A<7:5ZB GCD5u;

(325) 5G Uz<7Y

(326) ?G= F?X 58 5o58Y78585

(327) 585@p5

(328) CD 785<?

(329) ETTI|p5

(330) CD 78? L58?C5ETTK>F M7

(331) 5 5G7

(332)

(333) G 5G7 585?W 5S 7

(334) 7 5 586D7=R87<5 5HD585 5?5B58 5 N.

(335) 01234526738. 9.

(336)  !"#$% &'()* )+),+ ) -.)+/ )+012 *

(337) ) )+ )+3.45678

(338) ) )* 9: )+*; )-)

(339) ) )+- <. =>*)++??)@ ) )+3.45(.

(340) <.)@ )+37<5(.

(341) <.) )+A <B05(.

(342) <.)C+4*) ) 9D)+ )8 *)-4<. )3 5 3.4EFE5G)+,7 *)HFC7-)I7-J))+ )+7 ;)+ I011BKK. LMNOPQRSTPUPQVQWXYZ[\Y]UP^YQ]_`aSbQ]. 2 *

(343) ) )+ )+3.45HFC7-)-  7

(344)

(345) ))c7+d4* -<.)e)

(346)

(347) ))f ),4+ )E -.)+ -  '()* )+)012 *

(348) ) )+ )+3.45678

(349) )IJ))+ )+7 ;)+@011BK )c7* ; )3.45(.

(350) <.)HFC7-)

(351) ) )+- <. f/f>*)++??)@ ) )+3.45(.

(352) <.)@ )+37<5(.

(353) <.) )+A <B05(.

(354) <.)C+4*) )-4, ) )3 5 3.4EFE' 5 f78

(355) )IG

(356) 9. g@J))+ )+7 ;)+I011BKK;)+h78) )+678

(357) )

(358) ) *)*- <. G4 )8 +-?+/

(359) <.7-ijklmno -4

(360) )+*)3.4I37-.484

(361) 4dK5C+4*) 7 &'()5 * )+)-  3.49@37< A <B0 )-4 )+-*<.7+7c*)+ - )+*I27 7

(362) )7 9p)

(363) @ qr=KHFC7-) )+3.45678

(364) )(.)

(365)  ')s): '*+c*+ )37-5HFC7-) ' ))*.7

(366) *):,) ', *<.53) 4)@', *<.& ', *<.&&; )-) )) )+tu)c*4+5  Ht65&*)+7c* 49D)+ )8)*.7

(367) *) )C+4*) )) A5*)+8 7

(368) )

(369) )))-A99v5 24* GIAwAd-*) @9w9

(370) ?.7* -<.)98 4-(+)@vw )

(371) ) )98 4-(+)KIE4+) )*7

(372) @qq1K; )-)- )*7

(373) -' 7

(374) f/+ )?4-**+7-

(375) 7* 47

(376) )24 9c7* 4 )+C+4*) 5 ) +<.) )C+)d

(377) +??);+<. )-)24 9c7* 4@8) -*)-H)+7d

(378) 5H)+7d

(379) 54 )+ g.

(380) 01234526738 )* )+. ,- -.. 9

(381) ÿ 

(382) . 9

(383) ÿ ÿÿ. /00. /)-. 

(384)  

(385) !

(386) . /+. /+1 ""#$ 

(387) % !& '(  !

(388) . 233456789:;<=>?@ABCDEF?@AG HIJKCI LAG MGNDAEOA LAG P@NQRCBESEATU489VWV4XY8VZ [486 64V3V46V8 \8ZV]^_Z4`8[6`ab8V8 cde4ZXY \f\\gf64VhY`i\8[V]Z4`8 786 6^[j22ki l4m46a`64n_^Z4`8[io`Z4p. q^]8V[r5ihV[ZVfeV]6V864VhY`is]`ZV48V^8oVa3]^8V8]V_]7Z4V]Zc26^a[`8VZ^5;f :ttu^f3g;vV3V864V[V8486V8aV4[ZV8wxs^[V8y`]_`aaV86V8o`Z4yV8V8ZY^5ZV864V wxs^[V86V]hY`iq^a454VV48V_7]WVdVz7V8Wy`8:<2a48`[b7]V8f64V[`9V8^88ZVhY`i \8[V]Z4`8[6`ab8V;{4V[VpVY5Z6V8h^[is]`ZV48V8_`am5VZZ;{4Vq78_Z4`864V[V]\8[V]Z4`8 4[Z34[YV]V][ZZV45eV4[VXY^]^_ZV]4[4V]Z;|V46V]2_Z4y4V]7896V]sY`[mY`54m^[V{:csl{:g 67]XYj6X<uc}^5_V]^86|]`e8fu~~ugY^ZV48V{V5VZ4`86V]\8[V]Z4`8_V48V8U487[[ ^7p64V|4867896V]3V46V8s]`ZV48Vf^3V]`Y8VhY`i\8[V]Z4`8[6`ab8V_^88j6X<u64V sY`[mY`54m^[V{:84XYZaVY]^_Z4y4V]V8;U48VeV4ZV]Vq78_Z4`8p€]64V[VhV94`84[Z64V \8ZV]^_Z4`8a4Z6Va]V975^Z`]4[XYV8s]`ZV48hY`iw{\c}7VZ^5;f:ttg; {4VV][ZV8‚8ZV][7XY789V8y`8hY`is]`ZV48Ve7]6V8^8q43]`35^[ZV867]XY9Vp€Y]Zf Y`XYa`Z45V8ƒV55V8f3V46V]V8|VeV9789y4V5V‚a[Z]7_Z7]4V]789V86V[2_Z48WrZ`[_V5VZZ[ V]p`59V8;|V46V]\8„V_Z4`8y`8_`8[Z4Z7Z4y^_Z4yV8hY`is]`ZV48V848]7YV86Vq43]`35^[ZV8 e7]6V3V`3^XYZVZf6^[[64V[W7[Z^]_V8 V]b86V]789V86V[2_Z48WrZ`[_V5VZZp€Y]ZVch46i 5Vr^86†^55f:ttu‡h465VrVZ^5;f:ttug;h^X:[Z4a754V]Z64V27[3456789y`8l^aV554m`64V8 786ˆ‰ˆŠ‹Œ‰‹Ž‰ch465VrVZ^5;f:ttug;l^aV554m`64V8[486^39V^XYZVƒrZ`m5^[a^i ]V94`8V8f64V[4XY^86V8mV]4mYV]V8|V]V4XYV8y`8a`Z45V8ƒV55V8n86V8cda^55VZ^5;f u~~ug;d4V64V8V86V8ƒV55V8W7]q`]Z3VeV9789786W7] V]^8_V]789^a ‚8ZV]9]786; ‚8ZV]ˆ‰ˆŠ‹Œ‰‹Ž‰yV][ZVYZa^8|V]V4XYVf486V8V8[4XY64Vl^aV554m`64V8W7]€X_p^5i ZV8786eV55V8p‘]a49VdZ]7_Z7]V8^7[3456V8cda^55VZ^5;fu~~ug;|V]V4XYVf486V8V8y4V5V ˆ‰ˆŠ‹Œ‰‹Ž‰^7pZ]VZV8fWV49V8V48VY`YVo^_]`m48`WrZ`[Vi786sY^9`WrZ`[V^_Z4y4ZbZ cde^8[`8^86}^ZZ[f:tt’g;l^aV554m`64V8eV4[V8V4864XYZV[vVZWeV]_y`82_Z48n5^aV8i ZV8^7pf6^[Y^7mZ[bXY54XY^7[yV]WeV49ZV82_Z48n5^aV8ZV83V[ZVYZcda^55VZ^5;fu~~ug; \awV9V8[^ZWW7h^X:p€Y]Z64V\8„V_Z4`8y`8j6X<uW7]27[3456789y`8q45`m`64V8cv`i 3V[^86†^55f:tt’‡“`Wa^VZ^5;f:tt’g;q45`m`64V8[486Wr5486V]p‘]a49VƒV55^7[5b7pV]f 64V548V^]Vf78yV]WeV49ZV2_Z483€86V5V8ZY^5ZV8cda^55VZ^5;fu~~ug;d4V64V8V86V8ƒV55V8 W7]|VeV9789786W7]}^Y]8VYa789y`8V”`9V8V8hV4WV8cw7mZ`8^86wV]Z5V]fu~~g; U48Ve4XYZ49Vh`55V[m4V5V8q45`m`64V8W;|;3V4a 9V]4XYZVZV8}^XY[Z7a y`88V7]`8^5V8 ƒV55V8cdZ]^[[V]VZ^5;fu~~<g;vV7]`8^5VƒV55V8f486V8V864V\867_Z4`8y`8q45`m`64V8 •.

(389) . . 01234526738.  . 9

(390) . !"#$%&'()*+,$%-&.*'/0123,4(&.('50-67,8%+%(9:";<=>?@ABCDEFEG? E=HEIJ=KELMK>EEEG<ECK>EDNOK>DMEEKKD=P=EGENEE<CJQEG? HKKEKEDQ>RCHES>ETEEGUCJ=ETQ>EEHVEKWIEGMQ>MKXCDEG GJ=W>EEYEHGCDKGMKGTHKEGEZXEDJ=ENEEX>GKEIEK[J\]WEGKE ^Q>L>S>ETFENECD_XEGTED>I>=WG^EIECDCJ=WG`C=G? E=HEGaHEEE<=>GEEGKEDQ>bKGEDDXCDEGTCEMK? FETEHDKCE^EGEJ=EGNEEM>KGCMKEbKGMKGECDEWHVCJ=WE=E EDNEMPGSEGD`CJ=DKHDGJ=KEE:Q>=KKS!ccJEdHC>ECICJCK;:e;fEGEd? SGEDD>Q>M>DKKKQCMKQE[J\]<CJVgZhAh?LG>CDKEiEjdSGEDD>Q> [J\]XF=GKWGDQ>L>S>ETI_=GE<CJEDQ>RCHES>E WEGK:iS>HCGEKEDK=>GD;. =EGKIGTMPEWICG>J=IEKEG=ICJ=DETCEGDkEKEDED`CJ=DKH J=KHE=GEGJ=KEKDKCKK:bKGCDDEGEKCT]ll\;iEgmEMK>Q>M>DKKKQCMKQEH <=> G=EELG>CDKEXF=GKIEEGH WGDQ>CETSCGCEE MKFETED>ECKEbKGEDDXCDEG:<EOCZCTnn];iEDEEkEDJ= Q>GCEH H DKCEAEEGNEEEWDCHHEHKYO>D?Y>K>GSG>KEE M>KGCMKEbKGMKGETEEGNEEEEG<EKGCMK>EDDKCENEEGEJ=D=EXE :BEEGCYE>GT]llo;iEpGCDCK>EDMKWOK>DMEEKKDDSEKDED>EGE EHEGJ=KEKE`CJ=DKHQ>NEEEGB>CGK_KDEKEGHCK>EEIJ=KE<>? EVEEEDEBG>WEDDEDE<=>?@ABCDEKEGCEGEHCJ=CEGj>? jd>WOK>DEEKEKHLCQ><CJCEG^Q>GECMKQEbCEGDK>qDSEJED EEGgHHCKI>GKQ>YCJG>S=CECXKGCWE_GErGCM=EKDEGGEEG:<EOT ]lls[CKGET]llh; n.

(391) 01234526738. 9

(392)  . !"#$%&'()*+,-.(-.&/.0!1)2%&34/.%3-.&!&35678-&4-3%!3 !(.9:;<=>?>@ABAC>&D.3EFD2!&D!%!($.!1GHIIJKL(%4&3%MGHIIJNMO/P3. &33&)22.%-&G(%&&&&)22.Q-4!$.D3!(.Q.3&Q%!!3!R2DST%4 2%!(3M'()*+D443!!%27-%!-%.8D3&)2!U.1%!&4!5D.-!(&3%!S !.V7%2 5D!7-P.!$.D7&&!Q313G-!3.%!(.4 Q(.U.1%!&%3D!(& L3!S683D&33&G(.W!(D)83D&-!((.R1-%3D!5D!#.%!&./3D!EXD74!& 3%MG+JJJNMY!;<=>?>@ABAC>&3'()*+!&&!3&$.D3!MZ.(!6!43(4 34/.%3-.&!&35!=[=\]^_SL  Q!)23/.4&&5!#4/.%3-.!-35.3G&!( (6!!)2342.!(.`%17-!D&/!GDQ,D2 aLSR/%3D!-!((X.!S 3-!1!,3.2!&3%33b!(!EL(%4&3%MGHIIJNMcQ.d/.&&D!5D!'()*+:02.3 7-!4 V.-&3(&%d%!X!D&/-!1&4-&3.&K&D4437-!.7-:P1!O3S D!(.X!D&/-!1&&3!EFD2!&D!%!($.!1GHIIJNML-)2!2-4%!!6!,-.( !9D4DD17-'()*+(!3b7.3M&&&3!(.`%1G(! 32%!$2P!D38/!. '()*+S3D!!;<=>?>@ABAC>7-D4/4!3.!Ee-!43&-3%MGHIIJKO2!fD3%MG HIIJNMY!2g2.!6!713(Y!f3D!5D!D!&33-35%35!'()*+!!&3%.! Wh3%-:(U.1%!&%3D!(&683D&33&EXD74%3%MGHIIiNM%.0Q.2!%-&&3 '()*+!D)2%!5!,3.!7-P.!$.D7&&!Q313G,7MjM%!O1!%3.%!&(-S 3D!&5D.1P!1!-!((4V&3.%!&/D.3EX.D&)2,&3%MGHIII%NM. 9. 9klm n opqnonnrls. %4 Q&3!)2%.%3.&.3T-!3D!5D!'()*+&3(R1-%3D!(.L3!S U.1%!&%3D!M&.:D13!2g2.!6!(-.)2!Y!3.%3D!5D!%354 '()*+ 43(4 Z&D33SL(.)2O8!(.D4$.D3!EZLO$NQ7,M(4 5.,%!(3!$.D3!aS ZLO$Et>u?vtCwZLO$NEO84D!&3%MGHIIxKL&/!&3.D43%MGHIIxNMaSZLO$,-.( -.&/.0!1)2!!-.D!%!6!(!3b7.3GD443%Q.3.D37(&a%4!&-Qy-3P. 5D.M%&$.D3!!32P3!'()*+S&/7b&)2'RYjSD4P!E'()*+zR%)H!3.%)35 Q!(!1NEL&/!&3.D4 3%MGHIIxNMY4 -!1Q-!(!!6-&3%!(&3(%&$.D3!&D1S :%33G(%&&('RYjSD4P!%-3D!2Q3D.&)2,.3ELQ(-Se%!%!3%MGHIIIKX4 3%MG+JJJNMW!Y!3.%3D!43'()*+2Q3(L-3D!2Q3D!%-:-!(.4g1)23( Y!3.%3D!5D!aSZLO$43(4 %3!D.1%!&.!(!L./+z{SXD4/dEC=|At?>wC|>[ }?v|>AtNELQ(-Se%!%!3%MGHIIIKX43%MG+JJJKO3.%(% 3%MG+JJ*NML./+z{!(-S 7.3($D84.&%3D!5D!4D!D4.!L3!4D0!7-5.7,13!L3!b%4!3! E$D%.(G+JJ~NMY!;<=>?>@ABAC>,-.(!7-aSZLO$2D4DD1&$.D3!GjHG(!3bS HJ.

(393) 01234526738. 9.

(394)  !"#$%&'(%)($&*+,&-./010234 536078 9:

(395) ;<=>?;@A>BCD:E=F=G=

(396)

(397) ==<F:

(398) B;

(399) >9BH:<B;FD=<>@A = ==IB C

(400) JC = =K =B9:

(401) ;<=>?;@A>BCHLA<= =>:<C;

(402) =?;@A>BC> = =<9>

(403) D:=M =N:>9=>B;BBJC ; =<=K =B= 9:

(404) ;<=>?;@A>BC = =<O;;<><=;PB : =<Q

(405) D:RSTUUV>B;BBW = =XL

(406)

(407) =P:CCB=>G= =<9PB D =<D:Y @Z[\ H=

(408) @A=>H = =<C = =] =

(409) G;A

(410) D:I ;

(411) H==<=

(412) =<B^ =9PB D =<D:Y @Z[F_A<B

(413) =BGB=

(414) @AGC9:

(415) ;<=?;@A>BC <@A= =`=:<; >;B : =>9PB GaB:>P=

(416) =BB> =C ]=> P=

(417) B<;>9:<Bb;>8B ==Mc;=D

(418)

(419) =b[ddZee. G =<Bbf \gghe^ ==;=XPB :>H= >=D:Q== = =<9PB Mi<; >;B : >B:@A <=

(420) ;B DH=  =P;B\ ; =>=C O<:B=  =F_< =WB=<;PB :C BY @Z[:BH= = Y`WQM^:CL=F=A

(421) Bbf \gghe. jklkmnopqrstuvwxytuztrr{|rpuso}oyvu~€y~m. Q=>: =<>B >B =XPB :D:Y @Z[ = =<8B;

(422) =< =<J=

(423)

(424) 9:

(425) ;< BLB <@A =`=:<; >;B : =>9PB GaB:P=

(426) =BB>B=<>@AB?LA<= =>?;@A>BC>D:E=M F=G=

(427)

(428) ==<F:

(429) B =Q

(430) = =<==N:>9= <@AO:

(431) ;< > =< =<E=F=G=

(432)

(433) =W A;9

(434) : =J=

(435)

(436) =H=< ===N:>9== = =<= B>D:<A; ==‚=

(437) >;< =\ = ƒ =<<=>B=D:<A=<=A= =<J=

(438)

(439) B=

(440) =\;=

(441) =Bb;„ ;

(442) =>N:>9>C>B=<ebO<a= ; Q<=B>@A=<\[ddd \;eY @Z[ >BF_< =>=O<:G=>> =<= B> >=A<F<_A=IB; =:BM H=  B=C9=<;B<>=> B D=cB;B=D:Y @Z[>  =<= B> C  B ;

(443) =I@A< BB =< O:

(444) ;< > =< A =<Bb†:A>:; O< 

(445) =\ggde 8 =< =<=<>B=I@A< BB= = =<8B;

(446) =<= =<==N:>9>>B=

(447)

(448) = >B =

(449) :P;

(450) = .

(451) 01234526738 9

(452)  

(453)  

(454)  

(455) !  "#$ 

(456) %& !'((()*+  9

(457)  

(458)    !' ) ! ,   

(459)  +- , '

(460)

(461) . 

(462) ) !/ 0   #

(463) & 1

(464) ! 

(465)   "#$ 

(466) % !'((()*+2 / 0   '

(467) ! ,1! 30 ) 4, '

(468)  !.   & 

(469) 

(470) 0

(471) 

(472) !  ) 4/ 0   +-   #    5.#

(473) 6 7' /  0  

(474) "#

(475) 

(476) +'7889'7888*+ 6 7,  &5-:

(477)  3; ! 

(478) &  9  "3!

(479) 

(480) 

(481) +'((*+2

(482)

(483) , 4  1# 

(484)  +-  6

(485) 

(486)   9 $  ',!    /  0  0

(487)  ,+- 

(488)  0

(489)   9 $  ,  !<  = >0 >$

(490) /  0   )

(491) !"#$ 

(492) +'788?*+5! 

(493) 

(494)    -@$ & #  3A -@9(',!

(495)   '

(496) 9    ! <   !:  #

(497)

(498)  )

(499)  "B!

(500) 

(501) +'((?; 

(502) +' ((8*+C

(503)    #  ,! 5-:'

(504)  / 0@  5 0 % 7+% 7 !)

(505)  5 0.  ) ,# '

(506) -

(507) )  #

(508)   )  ". D 

(509) +'7888;% 

(510) +'((7;%$

(511) +'((*+

(512) ! ! ! % 7

(513) ' ,!  5-:

(514) 

(515) ! ,& 0E !-F    '

(516)    

(517) &3

(518) 

(519) 0E "% ((7'C

(520) G((A*+C 

(521) & ,  !  

(522) 9 

(523)  

(524)    / 0@ ! ) 4 " !&34 

(525) +'((A*+< ! ! '    #

(526) 1 &

(527) ! 

(528) ) ' 1

(529) 9 

(530)  

(531)  

(532)  ! '    

(533) #

(534) 1

(535) ) " !&34 

(536) +'((A*+2  !,

(537) ! 3

(538) ,! 0 600  1' !! 6& 

(539) 

(540)   9 $   ," !&34 

(541) +'((A*+2! 9 !  9 $  , !'

(542)

(543)  ! < . '  

(544)  3

(545) 0 !)

(546) &/  

(547) . !4!" !&34 

(548) +'((A*+5!, ,/ 0    #& 

(549)  

(550)  3 

(551) )   

(552)  #

(553) 1

(554) ! E@ "/), 

(555) +'((?*+. HIJIJKLMNOPQLRSTUVSWXYZQT[\YX.  

(556) ! ,!]

(557) 

(558)  < 

(559) 0 +9 E  !

(560) > )

(561)   5&900

(562) 

(563)  "^

(564) )

(565) 

(566) +'((*  

(567) . ^& 93# 90_A 

(568)  < 

(569) 0 `ab&5  0

(570) & 7.

(571) 01234526738 9

(572) 

(573) 9  .   !"#9

(574)  " $

(575) " %# 9

(576) %&'()*

(577) + #

(578) ,-"#'". 

(579)  "  /." 01

(580) 2.$

(581) # 34"  1." 

(582) 

(583) #56#

(584)  $.$

(585) .0

(586)

(587) " 7"  /." 4."$8$

(588) %#  #"3#.)#39.: . 6 

(589) 

(590) $ ;". 1 

(591)  <===62 ""  >. #

(592)  6 -"$##"7"  /." 4.*

(593) ?9 " "

(594) "$# @: .  4."   0

(595) #

(596) A 

(597) 

(598) $$4.%# #

(599)  '".0 6,  , 

(600)  

(601) ) ."$ 

(602)

(603) "#3

(604) $  , 0"-0,-"

(605) #:<. BCDEFGHIGFJGKLMNOGPNQB. BCDCBRSTNJFONUFVJWGOXYUVOHGIGUUOWZSQ[PNQB.  <

(606) $9

(607) %#4"1 # #.99

(608)  0 &"$ 

(609) 94."+) "6"$ #>"(\]^_`_abcbd_1"# "#

(610) $ 

(611)  <)e.9..$$,# .61.

(612) 4

(613)  #"'

(614) 04.".99  "  fA

(615)  . # ".) 1

(616) 0f <1"#" /"-$

(617)   g6 " ,-"#

(618)  >')

(619) 6. :

(620) "$#"#. %h)7.9

(621) 4.ijkcl`bmbno pklnjbqno

(622) #

(623) r0

(624) " >

(625) # 6": <=s=g/8 "  

(626) "  #  <" "

(627) t

(628) 4"

(629) 6. :

(630) " 1

(631) "# "# <==>

(632) 

(633) $ ) 

(634) @

(635) /". 

(636) # %h)7.9

(637) 

(638) #.)'". 

(639)   <"$

(640) " #

(641) "."$ 

(642) )

(643) .# 

(644) 0: .  >

(645)  <)4"9

(646)   

(647) ."$ 

(648)

(649) .r#

(650) 9 2$ 0 0%#

Referenzen

ÄHNLICHE DOKUMENTE

Die Zellen wurden durch Zentrifugieren 3.500 Upm, 5min, RT, Heraeus Biofuge pico pelletiert und anschließend für eine Zelldichte von OD600 = 2 in einem entsprechenden Volumen

Durch chemisch-genetische Analyse der Don3 Kinase konnte gezeigt werden, dass die Umwandlung des Septincollars in einen Ring nicht durch eine mechanische Rotation

So konnte gezeigt werden, dass diese 12 koregulierten Gene einem Gencluster angehören, welches unter Stickstoffmangelbedingungen exprimiert wird und das vermutlich

Um Rückschlüsse über die Rolle der einzelnen Protein-Protein- Interaktionen für die pathogene Entwicklung zu erlangen, wurden die Bereiche des Clp1-Proteins, die für

Die Experimente zeigten, dass Indolpyruvat spontan, entweder alleine oder in Kombination mit Tryptophan, in wässriger Umgebung zu einer Vielzahl von farbigen Substanzen

Mittels Pep1-GFP- und mCherry-Fusionen konnte gezeigt werden, dass das Protein in die biotrophe Interaktionszone zwischen Pilz und Pflanze in den

maydis Genom konnten 6,902 Protein-codierende Gene vorhergesagt werden, wobei für 426 Proteine eine hohe Sekretionswahrscheinlichkeit gezeigt werden konnte, die

Eine hierarchische Cluster-Analyse (Skript siehe CD im Anhang) unter diesen Stringenzbedingungen ergab, dass nach Infektion mit SG200 8 Gene signifikant in ihrer Expression