Supplementary table 1. Clinical characteristics of patients with relapses of CMV-DNAemia or CMV diseases
Pt number
Sex Age Primary disease
Donor source
CMV serostatus
Days to CMV- DNAemia
Viral load at initial onset (copies/mL)
Peak viral load at initial onset
CMV disease
Days to antiviral therapy
CMV treatment
Duration of CMV- DNAemia at initial onset
DRMs Outcome
1 M 10y TM Haplo R+D+ 31 days 4.39×102 1.15×104 Pneumonia 7 days GCV+FOS 27 days None No relapse.
3 M 9y TM Haplo R+D+ 42 days 4.95×102 7.13×102 None - No
antiviral treatment
18 days None One relapse of CMV- DNAemia.
12 M 6y TM Haplo R+D+ 39 days 5.19×103 7.95×105 Pneumonia
and retinitis
1 day GCV+FOS 44 days None One relapse of CMV disease.
Blindness of the right eye caused by CMV retinitis.
19 F 9y TM Haplo R+D+ 35 days 1.68×103 2.40×103 None 1 day GCV 13 days UL54 –
L999I
One relapse of CMV- DNAemia.
22 M 11y TM Haplo R+D+ 60 days 2.25×103 2.25×103 Pneumonia 0 day GCV 17 day None No relapse.
27 F 5y TM Haplo R+D+ 33 days 5.42×102 2.31×103 None 0 day GCV 6 days None Two relapses
of CMV- DNAemia after the first episode.
29 F 9y TM MUD R-D+ 34 days 1.53×104 1.53×104 Pneumonia 0 day GCV+FOS - UL54 – T691A, G604S
Died of CMV pneumonia on Day+54 post- HSCT.
30 M 3y TM MUD R+D+ 36 days 1.16×104 1.16×104 Pneumonia 0 day GCV+FOS 44 days None One relapse of
CMV disease.
CMV – cytomegalovirus; CTL – cytotoxic T lymphocyte; D – donor; FOS – foscarnet; GCV –ganciclovir; HSCT – hematopoietic stem cell transplantation; MUD – matched unrelated donor; R – recipient; TM – thalassemia major.
