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Table S2. Compounds in validation set with known protein targets knocked down in 4 or more LINCS cell lines.

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Table S2. Compounds in validation set with known protein targets knocked down in 4 or more LINCS cell lines. Parentheses in the rightmost column indicate the predicted ranking of each known target out of over 3000 potential targets.

NAME ID RANKED TARGETS

vincristine BRD-A76528577 TUBA1A (17), TUBB6 (159) paclitaxel BRD-A23723433 TUBA1A (141), TUBB6 (86)

vincristine BRD-K82109576 TUBA1A (74), TUBB2C (1656), TUBB6 (288), TUBB2A (108)

bortezomib BRD-K88510285 PSMB7 (86), PSMA3 (27), PSMA5 (70), PSMB5 (22), PSMA1 (40), PSMA8 (195), PSMB10 (424)

dasatinib BRD-K49328571 YES1 (1039), LCK (649) sibutramine BRD-A23359898 NAT1 (1855), NET1 (2044) vinorelbine BRD-K10916986 TUBA1A (14), TUBB6 (95)

alitretinoin BRD-K35483542 RARA (2616), RARG (126), RXRA (175) paclitaxel BRD-A28746609 TUBA1A (1), TUBB6 (116)

vinorelbine BRD-K97514127 TUBA1A (48), TUBB2C (2977), TUBB6 (264), TUBB2A (450)

vincristine BRD-A60414806 TUBA1A (9), TUBB6 (23) vinblastine BRD-A22783572 TUBA1A (1), TUBB6 (46) vinblastine BRD-A55594068 TUBA1A (6), TUBB6 (137)

vinorelbine BRD-M30523314 TUBA1A (152), TUBB2C (1670), TUBB6 (344), TUBB2A (419)

alprazolam BRD-K32398298 GABRP (2285), GABRG1 (2284) pentobarbital BRD-A44448661 GABRP (1377), GABRG1 (2577)

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