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Ischemia-Responsive Protein (irp94) Is Up-Regulated by Endoplasmic Reticulum Stress

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Ischemia-Responsive Protein (irp94) Is Up-Regulated by Endoplasmic Reticulum Stress

Seung-Whan Kim

a

, In-Sool Yoo

a

, Hyeon-Song Koh

b

and O-Yu Kwon

c,

*

a Department of Emergency Medicine, Chungnam National University Hospital, Taejon 301Ð040, Korea

b Department of Neurosurgery, Chungnam National University Hospital, Taejon 301Ð040, Korea

c Department of Anatomy, College of Medicine, Chungnam National University, Taejon 301Ð747, Korea. Fax: 82-42-586-4800.

E-mail: oykwon@cnu.ac.kr

* Author for correspondence and reprint requests Z. Naturforsch.56c,1169Ð1171 (2001);

received September 9/October 22, 2001

Ischemia Responsive Protein (irp94), Endoplasmic Reticulum (ER), FRTL-5 Cells

The expression of the ischemia-responsive protein (irp94) was enhanced by endoplasmic reticulum (ER) stress inducing drugs such as brefeldin A (BFA), calcium ionophor A23187, dithiothreitol (DTT) and tunicamycin in fisher rat thyroid epithelial cell line (FRTL-5 cells). In particular, irp94 mRNA expression was increased dose dependently by tunicamycin, and there was increased irp94 expression when the cells were incubated with the thyroid-stimulating hormone (TSH) together.

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