Nickel(II) Affects Poly(ADP-ribose) Polymerase-Mediated DNA Repair in Normal and Cancer Cells

Analysis of PAR in PBMCs treated ex vivo with PARP inhibitors, suggested that the method described can served as a bioanalytical tool in cancer therapy for testing PARP

The exact function of PARP1 in BER is still under debate, however it has been observed that directly induced SSB are bound by PARP1 (and PARP2), which then recruits the other

found that the poly(ADP-ribosyl)ation capacity of the hPARP-1 is significantly higher than that of its rodent (rat) orthologue (Beneke et al. 2000), thus paving the way for the

To clarify the role of PARPs on telomere regulation, we used cells from two mammalian species (hamster and human) and inhibited PARP activity either pharmacolo- gically or

Treatment of experimentally induced diabetes in rats or established diabetes in a genetic mouse model (non obese diabetes, NOD) with PARP inhibitors reduced oxidative stress

Its overexpression leads to an increased DNA repair capacity after X-irradiation, but on the other hand also to an increased susceptibility to DNA damage in response to

For example, both short and long polymers can interact with the tumour sup- pressor protein p53, while under the same experimental conditions the nucleotide excision

Eine mögliche Ursache, warum die PARP-1- Überexpression in den Mutanten keinen Effekt auf die Invasion und Replikation der Parasiten hatte, könnte in dem vergleichbar niedrigen