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1 Table 2. Results of ANCOVA predicting impulsivity measures at 25 years of age based on serum lipid levels separately at 9, 15 and 18 years of

age by gender. Covariates included cohort, psychiatric disorders, medications, alcohol and illicit substance use, smoking and maltreatment.

Regression coefficients b presenting the effect size and direction and p-values are presented.

MALES

Disinhibition Thoughtlessness Excitement seeking Fast decision making

b p b p b p b p

9 years

TC -1.88 <0.001 -2.05 <0.01 -0.01 0.99 0.33 0.63

HDL -3.92 <0.01 -3.96 0.01 0.81 0.58 0.54 0.75

LDL -1.74 <0.01 -2.13 <0.01 -0.09 0.89 0.28 0.73

TRG -1.60 0.299 -0.63 0.75 -0.46 0.79 1.98 0.33

15 years TC -1.43 <0.001 -1.39 <0.01 1.03 0.04 1.02 0.04

HDL -2.53 0.10 -1.58 0.21 1.54 0.20 3.05 0.01

LDL -1.51 <0.01 -1.60 0.01 0.81 0.19 0.38 0.49

TRG 0.39 0.59 0.14 0.87 0.40 0.66 0.84 0.36

18 years TC -1.15 <0.01 -1.04 0.04 0.91 0.07 0.73 0.14

(2)

2

HDL -2.59 <0.01 -1.85 0.12 2.97 0.01 1.72 0.13

LDL -0.81 0.07 -0.95 0.01 0.60 0.28 0.57 0.30

TRG 0.83 0.12 0.70 0.29 -0.89 0.17 -0.27 0.67

FEMALES

Disinhibition Thoughtlessness Excitement seeking Fast decision making

b p b p b p b p

9 years

TC 0.15 0.81 -0.23 0.73 0.38 0.60 -0.87 0.24

HDL -0.01 1.00 1.23 0.50 1.31 0.49 -0.39 0.84

LDL 0.37 0.61 -0.52 0.54 0.25 0.77 -1.06 0.24

TRG 0.47 0.78 0.06 0.98 1.55 0.43 0.54 0.79

15 years TC -0.20 0.62 -0.43 0.34 -0.07 0.88 -0.52 0.27

HDL -0.98 0.29 -0.60 0.54 1.08 0.31 0.25 0.81

LDL -0.37 0.39 -0.63 0.22 -0.66 0.24 -0.95 0.08

TRG 0.02 0.98 -0.04 0.96 0.01 0.99 -0.33 0.72

18 years TC -0.04 0.89 0.20 0.61 0.13 0.77 -0.08 0.84

(3)

3

HDL -0.33 0.66 -0.46 0.59 1.79 0.07 0.83 0.37

LDL -0.17 0.67 -0.13 0.78 -0.26 0.62 -0.41 0.40

TRG 0.03 0.97 1.10 0.13 -0.63 0.44 -0.10 0.89

Total cholesterol (TC), HDL cholesterol (HDL), LDL cholesterol (LDL), triglycerides (TRG). P-value marked in bold while significant at p<0.05.

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