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A B
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A B
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A B
Translated intron
A
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A B C
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Sequence similarity Deduced annotation for sequence B
Case
Correct functional inference
: |: :: | : : || | :
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| ||: | || | Inferred function corresponds to
non−homologous domain 2
| ||: | || | Inferrred function is incomplete
requiring further investigation of domain 2
1 2 1 2
1 2
| ||:| |||: :|| ||:||| |:||| Assignment of homology is accurate,
but non−conservation of some residues results in inaccurate functional inference
| ||:| |||: :|| ||:||| |:||| Protein A has been wrongly characterised
resulting in false inference of protein B function
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