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Activation of Hematoporphyrin in Alternating Magnetic Field: Possible Implications for Cancer Treatment

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Activation of Hematoporphyrin in Alternating Magnetic Field:

Possible Implications for Cancer Treatment Mela´nia Babincova´

a,

*, Phoumyphone Sourivong

b

, Danuta Leszczynska

c

and Peter Babinec

a

a Department of Biophysics and Chemical Physics, Comenius University, MFF UK, Mlynska´ dolina F1, 842 15 Bratislava, Slovakia.

Fax: +(421)-7Ð654Ð25Ð882.

E-mail: babincova@fmph.uniba.sk

b Physics Department, University of North Dakota, Grand Fork, ND 58202, USA

c Department of Civil Engineering, FAMU-FSU College of Engineering, Tallahassee, FL 32310, USA

* Author for correspondnce and reprint request Z. Naturforsch.54c,993Ð995 (1999);

received May 20/August 9, 1999

Hematoporphyrin, Alternating Magnetic Field, Glioblastoma Cell, Cancer Treatment

A new mechanism of cell damage by alternating mag- netic field with hematoporphyrin is described. C6 gli- oblastoma cell suspensions were exposed to an alternat- ing magnetic field with frequency 180 kHz up to 60 min in the presence of hematoporphyrin in H2O and in D2O.

The results presented suggest that an alternating mag- netic field is able to activate hematoporphyrin, and this method may be a basis for cancer treatment.

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